Liver-stage Plasmodium infection tunes clinical outcomes

Alexis Kaushansky; Nana Minkah

doi:10.1016/j.pt.2023.03.004

Liver-stage Plasmodium infection tunes clinical outcomes

Trends Parasitol. 2023 May;39(5):321-322. doi: 10.1016/j.pt.2023.03.004. Epub 2023 Mar 17.

Authors

Alexis Kaushansky¹, Nana Minkah²

Affiliations

¹ Department of Pediatrics, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA. Electronic address: alexis.kaushansky@seattlechildrens.org.
² Department of Pediatrics, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA. Electronic address: nana.minkah@seattlechildrens.org.

PMID: 36935339
PMCID: PMC10634323 (available on 2024-05-01)
DOI: 10.1016/j.pt.2023.03.004

Abstract

Chora and colleagues show that infection of the liver by Plasmodium modulates severity of disease in the experimental cerebral malaria (ECM) model by generating gamma delta (ɣδ) T cells that produce IL-17. This work calls into question the long-standing assumption that liver infection does not modulate severity of malaria.

Keywords: IL-17; erythropoiesis; experimental cerebral malaria; liver-stage Plasmodium immunity; natural immunity to malaria; ɣδ T cell.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Communicable Diseases*
Humans
Liver Diseases*
Malaria, Cerebral*
Plasmodium berghei

Abstract

Publication types

MeSH terms

Grants and funding